NAD+/NADH redox alterations reconfigure metabolism and rejuvenate senescent human mesenchymal stem cells in vitro

NAD+/NADH redox alterations reconfigure metabolism and rejuvenate senescent human mesenchymal stem cells in vitro

Yuan et al. characterise metabolic profiles of human mesenchymal stem cells (hMSCs) during cell expansion in culture. They find that late passage hMSCs exhibit a NAD + /NADH redox cycle imbalance and that adding NAD + precursor nicotinamide restores mitochondrial fitness and cellular homeostasis in...

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Bibliographic Details
Main Authors: Xuegang Yuan, Yijun Liu, Brent M. Bijonowski, Ang-Chen Tsai, Qin Fu, Timothy M. Logan, Teng Ma, Yan Li
Format: Article
Language:English
Published: Nature Portfolio 2020-12-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-020-01514-y

Internet

https://doi.org/10.1038/s42003-020-01514-y

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