Constitutive translation of human α-synuclein is mediated by the 5′-untranslated region

Genetic and biochemical studies have established a central role for α-synuclein (SNCA) accumulation in the pathogenesis of Parkinson's disease. Uncovering and subsequently interfering with physiological mechanisms that control SNCA expression is one approach to limit disease progression. To thi...

Full description

Bibliographic Details
Main Authors: Pelagia Koukouraki, Epaminondas Doxakis
Format: Article
Language:English
Published: The Royal Society 2016-01-01
Series:Open Biology
Subjects:
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.160022