Mifepristone Overcomes Tumor Resistance to Temozolomide Associated with DNA Damage Repair and Apoptosis in an Orthotopic Model of Glioblastoma

Mifepristone Overcomes Tumor Resistance to Temozolomide Associated with DNA Damage Repair and Apoptosis in an Orthotopic Model of Glioblastoma

The standard treatment for glioblastoma multiforme (GBM) is surgery followed by chemo/radiotherapy. A major limitation on patient improvement is the high resistance of tumors to drug treatment, likely responsible for their subsequent recurrence and rapid progression. Therefore, alternatives to the s...

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Bibliographic Details
Main Authors: Monserrat Llaguno-Munive, Mario Romero-Piña, Janeth Serrano-Bello, Luis A. Medina, Norma Uribe-Uribe, Ana Maria Salazar, Mauricio Rodríguez-Dorantes, Patricia Garcia-Lopez
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Cancers
Subjects:
glioblastoma
temozolomide
mifepristone
MGMT
drug resistance
apoptosis
Online Access:http://www.mdpi.com/2072-6694/11/1/16

Internet

http://www.mdpi.com/2072-6694/11/1/16

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