(−)-Epigallocatechin-3-Gallate Diminishes Intra-and Extracellular Amyloid-Induced Cytotoxic Effects on Cholinergic-like Neurons from Familial Alzheimer’s Disease PSEN1 E280A

(−)-Epigallocatechin-3-Gallate Diminishes Intra-and Extracellular Amyloid-Induced Cytotoxic Effects on Cholinergic-like Neurons from Familial Alzheimer’s Disease PSEN1 E280A

Alzheimer’s disease (AD) is a complex neurodegenerative disease characterized by functional disruption, death of cholinergic neurons (ChNs) because of intracellular and extracellular Aβ aggregates, and hyperphosphorylation of protein TAU (p-TAU). To date, there are no efficient therapies against AD....

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Bibliographic Details
Main Authors: Viviana Soto-Mercado, Miguel Mendivil-Perez, Carlos Velez-Pardo, Marlene Jimenez-Del-Rio
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Biomolecules
Subjects:
cholinergic neurons
epigallocatechin-3-gallate
phytochemical
polyphenol
familial Alzheimer disease
PSEN1
Online Access:https://www.mdpi.com/2218-273X/11/12/1845

Internet

https://www.mdpi.com/2218-273X/11/12/1845

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