Drp1 SUMO/deSUMOylation by Senp5 isoforms influences ER tubulation and mitochondrial dynamics to regulate brain development

Drp1 SUMO/deSUMOylation by Senp5 isoforms influences ER tubulation and mitochondrial dynamics to regulate brain development

Summary: Brain development is a highly orchestrated process requiring spatiotemporally regulated mitochondrial dynamics. Drp1, a key molecule in the mitochondrial fission machinery, undergoes various post-translational modifications including conjugation to the small ubiquitin-like modifier (SUMO)....

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Bibliographic Details
Main Authors: Seiya Yamada, Ayaka Sato, Naotada Ishihara, Hiroki Akiyama, Shin-ichi Sakakibara
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:iScience
Subjects:
Cellular neuroscience
Molecular neuroscience
Molecular physiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221014553

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http://www.sciencedirect.com/science/article/pii/S2589004221014553

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