Proteome and secretome profiling of zinc availability in Cryptococcus neoformans identifies Wos2 as a subtle influencer of fungal virulence determinants

Proteome and secretome profiling of zinc availability in Cryptococcus neoformans identifies Wos2 as a subtle influencer of fungal virulence determinants

Abstract Background Fungal infections impact over 25% of the global population. For the opportunistic fungal pathogen, Cryptococcus neoformans, infection leads to cryptococcosis. In the presence of the host, disease is enabled by elaboration of sophisticated virulence determinants, including polysac...

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Bibliographic Details
Main Authors: B. Ball, E. Woroszchuk, A. Sukumaran, H. West, A. Afaq, D. Carruthers-Lay, B. Muselius, L. Gee, M. Langille, S. Pladwig, S. Kazi, A. Hendriks, J. Geddes-McAlister
Format: Article
Language:English
Published: BMC 2021-12-01
Series:BMC Microbiology
Subjects:
Cryptococcus neoformans
Fungal pathogenesis
Zinc limitation
Quantitative proteomics
Polysaccharide capsule
Virulence
Online Access:https://doi.org/10.1186/s12866-021-02410-z

Internet

https://doi.org/10.1186/s12866-021-02410-z

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