Ablation of liver Fxr results in an increased colonic mucus barrier in mice

Ablation of liver Fxr results in an increased colonic mucus barrier in mice

Background & Aims: The interorgan crosstalk between the liver and the intestine has been the focus of intense research. Key in this crosstalk are bile acids, which are secreted from the liver into the intestine, interact with the microbiome, and upon absorption reach back to the liver. The b...

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Main Authors: Noortje Ijssennagger, Kristel S. van Rooijen, Stefanía Magnúsdóttir, José M. Ramos Pittol, Ellen C.L. Willemsen, Marcel R. de Zoete, Matthijs J.D. Baars, Paul B. Stege, Carolina Colliva, Roberto Pellicciari, Sameh A. Youssef, Alain de Bruin, Yvonne Vercoulen, Folkert Kuipers, Saskia W.C. van Mil
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:JHEP Reports
Subjects:
Farnesoid X receptor
Liver-specific Fxr-KO mouse
Intestine-specific Fxr-KO mouse
Colon
Gut microbiome
Mucus layer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555921001208

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http://www.sciencedirect.com/science/article/pii/S2589555921001208

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