New Deferoxamine Glycoconjugates Produced upon Overexpression of Pathway-Specific Regulatory Gene in the Marine Sponge-Derived Streptomyces albus PVA94-07

New Deferoxamine Glycoconjugates Produced upon Overexpression of Pathway-Specific Regulatory Gene in the Marine Sponge-Derived Streptomyces albus PVA94-07

Activation of silent biosynthetic gene clusters in Streptomyces bacteria via overexpression of cluster-specific regulatory genes is a promising strategy for the discovery of novel bioactive secondary metabolites. This approach was used in an attempt to activate a cryptic gene cluster in a marine spo...

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Bibliographic Details
Main Authors: Olga N. Sekurova, Ignacio Pérez-Victoria, Jesús Martín, Kristin F. Degnes, Håvard Sletta, Fernando Reyes, Sergey B. Zotchev
Format: Article
Language:English
Published: MDPI AG 2016-08-01
Series:Molecules
Subjects:
Streptomyces
secondary metabolite biosynthesis
gene cluster
regulatory gene
deferoxamine
glycoconjugates
Online Access:http://www.mdpi.com/1420-3049/21/9/1131

Internet

http://www.mdpi.com/1420-3049/21/9/1131

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