Increased pain unpleasantness and pain-related fMRI activation in the periaqueductal gray in Alzheimer's disease

Increased pain unpleasantness and pain-related fMRI activation in the periaqueductal gray in Alzheimer's disease

BackgroundPain continues to be underrecognized and undertreated in people with Alzheimer's disease (AD). The periaqueductal gray (PAG) is essential to pain processing and modulation yet is damaged by AD. While evidence exists of altered neural processing of pain in AD, there has not been a focu...

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Bibliographic Details
Main Authors: Alison R. Anderson, Todd B. Monroe, Mary S. Dietrich, Stephen P. Bruehl, W. Larkin Iversen, Ronald L. Cowan, Michelle D. Failla
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Pain Research
Subjects:
Alzheimer disease
dementia
pain
periaqueductal gray
neuroimaging
fMRI
Online Access:https://www.frontiersin.org/articles/10.3389/fpain.2022.914473/full

Internet

https://www.frontiersin.org/articles/10.3389/fpain.2022.914473/full

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