HIV-1 Vpu Promotes Phagocytosis of Infected CD4<sup>+</sup> T Cells by Macrophages through Downregulation of CD47

HIV-1 Vpu Promotes Phagocytosis of Infected CD4<sup>+</sup> T Cells by Macrophages through Downregulation of CD47

ABSTRACT Human immunodeficiency virus (HIV) remodels the cell surface of infected cells to facilitate viral dissemination and promote immune evasion. The membrane-associated viral protein U (Vpu) accessory protein encoded by HIV-1 plays a key role in this process by altering cell surface levels of m...

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Bibliographic Details
Main Authors: Lijun Cong, Scott M. Sugden, Pascal Leclair, Chinten James Lim, Tram N. Q. Pham, Éric A. Cohen
Format: Article
Language:English
Published: American Society for Microbiology 2021-08-01
Series:mBio
Subjects:
CD47
HIV
HIV dissemination
HIV infection
Vpu
macrophage reservoir
Online Access:https://journals.asm.org/doi/10.1128/mBio.01920-21

Internet

https://journals.asm.org/doi/10.1128/mBio.01920-21

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