Characterization of the brain 26S proteasome and its interacting proteins

Proteasome-mediated proteolysis is important for synaptic plasticity, neuronal development, protein quality control, and many other processes in neurons. To define proteasome composition in brain, we affinity purified 26S proteasomes from cytosolic and synaptic compartments of the rat cortex. Using...

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Bibliographic Details
Main Authors: Hwan-Ching Tai, Henrike Besche, Alfred L Goldberg, Erin M Schuman
Format: Article
Language:English
Published: Frontiers Media S.A. 2010-05-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2010.00012/full