Tumor treatment by pHLIP-targeted antigen delivery

Targeted antigen delivery allows activation of the immune system to kill cancer cells. Here we report the targeted delivery of various epitopes, including a peptide, a small molecule, and a sugar, to tumors by pH Low Insertion Peptides (pHLIPs), which respond to surface acidity and insert to span th...

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Bibliographic Details
Main Authors: Michael DuPont, Hannah Visca, Anna Moshnikova, Donald M. Engelman, Yana K. Reshetnyak, Oleg A. Andreev
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2022.1082290/full