Unbiased proteomics, histochemistry, and mitochondrial DNA copy number reveal better mitochondrial health in muscle of high-functioning octogenarians

Unbiased proteomics, histochemistry, and mitochondrial DNA copy number reveal better mitochondrial health in muscle of high-functioning octogenarians

Background: Master athletes (MAs) prove that preserving a high level of physical function up to very late in life is possible, but the mechanisms responsible for their high function remain unclear. Methods: We performed muscle biopsies in 15 octogenarian world-class track and field MAs and 14 non-at...

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Bibliographic Details
Main Authors: Ceereena Ubaida-Mohien, Sally Spendiff, Alexey Lyashkov, Ruin Moaddel, Norah J MacMillan, Marie-Eve Filion, Jose A Morais, Tanja Taivassalo, Luigi Ferrucci, Russell T Hepple
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-04-01
Series:eLife
Subjects:
skeletal muscle
mitochondria
proteomics
physical activity
exercise
frailty
Online Access:https://elifesciences.org/articles/74335

Internet

https://elifesciences.org/articles/74335

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