Anthrax edema factor toxicity is strongly mediated by the N-end rule.

Anthrax edema factor (EF) is a calmodulin-dependent adenylate cyclase that converts adenosine triphosphate (ATP) into 3'-5'-cyclic adenosine monophosphate (cAMP), contributing to the establishment of Bacillus anthracis infections and the resulting pathophysiology. We show that EF adenylate...

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Bibliographic Details
Main Authors: Clinton E Leysath, Damilola D Phillips, Devorah Crown, Rasem J Fattah, Mahtab Moayeri, Stephen H Leppla
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3755998?pdf=render