HOTAIR interacts with PRC2 complex regulating the regional preadipocyte transcriptome and human fat distribution

HOTAIR interacts with PRC2 complex regulating the regional preadipocyte transcriptome and human fat distribution

Summary: Mechanisms governing regional human adipose tissue (AT) development remain undefined. Here, we show that the long non-coding RNA HOTAIR (HOX transcript antisense RNA) is exclusively expressed in gluteofemoral AT, where it is essential for adipocyte development. We find that HOTAIR interacts...

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Bibliographic Details
Main Authors: Feng-Chih Kuo, Matt J. Neville, Rugivan Sabaratnam, Agata Wesolowska-Andersen, Daniel Phillips, Laura B.L. Wittemans, Andrea D. van Dam, Nellie Y. Loh, Marijana Todorčević, Nathan Denton, Katherine A. Kentistou, Peter K. Joshi, Constantinos Christodoulides, Claudia Langenberg, Philippe Collas, Fredrik Karpe, Katherine E. Pinnick
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Cell Reports
Subjects:
subcutaneous adipose tissue
fat distribution
lncRNA
HOTAIR
adipogenesis
epigenetic regulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124722009457

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http://www.sciencedirect.com/science/article/pii/S2211124722009457

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