The factor inhibiting HIF regulates T cell differentiation and anti-tumour efficacy

The factor inhibiting HIF regulates T cell differentiation and anti-tumour efficacy

T cells must adapt to variations in tissue microenvironments; these adaptations include the degree of oxygen availability. The hypoxia-inducible factor (HIF) transcription factors control much of this adaptation, and thus regulate many aspects of T cell activation and function. The HIFs are in turn...

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Bibliographic Details
Main Authors: David Bargiela, Pedro P. Cunha, Pedro Veliça, Lena C. M. Krause, Madara Brice, Laura Barbieri, Milos Gojkovic, Iosifina P. Foskolou, Helene Rundqvist, Randall S. Johnson
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Immunology
Subjects:
hypoxia-inducible factor
factor inhibiting HIF
T cells
immunotherapy
imunometabolism
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1293723/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1293723/full

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