Thrombospondin1 mimics rapidly relieve depression via Shank3 dependent uncoupling between dopamine D1 and D2 receptors

Thrombospondin1 mimics rapidly relieve depression via Shank3 dependent uncoupling between dopamine D1 and D2 receptors

Summary: Deficits in astrocyte function contribute to major depressive disorder (MDD) and suicide, but the therapeutic effect of directly reactivating astrocytes for depression remains unclear. Here, specific gains and losses of astrocytic cell functions in the medial prefrontal cortex (mPFC) bidire...

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Bibliographic Details
Main Authors: Shuang-Qi Gao, Jun-Quan Chen, Hai-Yun Zhou, Lun Luo, Bao-Yu Zhang, Man-Ting Li, Hai-Yong He, Chuan Chen, Ying Guo
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:iScience
Subjects:
Biological sciences
Neuroscience
Proteomics
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223005655

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http://www.sciencedirect.com/science/article/pii/S2589004223005655

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