Germline Mutations in Other Homologous Recombination Repair-Related Genes Than <i>BRCA1/2</i>: Predictive or Prognostic Factors?
The homologous recombination repair (HRR) pathway repairs double-strand DNA breaks, mostly by BRCA1 and BRCA2, although other proteins such as ATM, CHEK2, and PALB2 are also involved. <i>BRCA1/2</i> germline mutations are targeted by PARP inhibitors. The aim of this commentary is to expl...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-03-01
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| Series: | Journal of Personalized Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4426/11/4/245 |