The Beta Adrenergic Receptor Blocker Propranolol Counteracts Retinal Dysfunction in a Mouse Model of Oxygen Induced Retinopathy: Restoring the Balance between Apoptosis and Autophagy

The Beta Adrenergic Receptor Blocker Propranolol Counteracts Retinal Dysfunction in a Mouse Model of Oxygen Induced Retinopathy: Restoring the Balance between Apoptosis and Autophagy

In a mouse model of oxygen induced retinopathy (OIR), beta adrenergic receptor (BAR) blockade has been shown to recover hypoxia-associated retinal damages. Although the adrenergic signaling is an important regulator of apoptotic and autophagic processes, the role of BARs in retinal cell death remain...

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Bibliographic Details
Main Authors: Maurizio Cammalleri, Filippo Locri, Elisabetta Catalani, Luca Filippi, Davide Cervia, Massimo Dal Monte, Paola Bagnoli
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
beta adrenergic receptors
propranolol
proliferative retinopathies
retinal neurons
apoptosis
autophagy
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2017.00395/full

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http://journal.frontiersin.org/article/10.3389/fncel.2017.00395/full

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