Impaired Control of Epstein–Barr Virus Infection in B-Cell Expansion with NF-κB and T-Cell Anergy Disease

Impaired Control of Epstein–Barr Virus Infection in B-Cell Expansion with NF-κB and T-Cell Anergy Disease

B-cell expansion with NF-κB and T-cell anergy (BENTA) disease is a B-cell-specific lymphoproliferative disorder caused by germline gain-of-function mutations in CARD11. These mutations force the CARD11 scaffold into an open conformation capable of stimulating constitutive NF-κB activation in lymphoc...

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Bibliographic Details
Main Authors: Swadhinya Arjunaraja, Pamela Angelus, Helen C. Su, Andrew L. Snow
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Immunology
Subjects:
Epstein–Barr virus
B-cell expansion with NF-κB and T-cell anergy
CARD11
NF-κB
primary immune deficiency
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00198/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00198/full

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