A reverse translational study of PPAR-α agonist efficacy in human and rodent models relevant to alcohol use disorder

A reverse translational study of PPAR-α agonist efficacy in human and rodent models relevant to alcohol use disorder

Alcohol Use Disorder (AUD) is a chronic relapsing disorder affecting an estimated 283 million individuals worldwide, with substantial health and economic consequences. Peroxisome proliferator-activated receptors (PPARs), particularly PPAR-α and PPAR-γ, have shown promise in preclinical studies as po...

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Bibliographic Details
Main Authors: Barbara J. Mason, David Estey, Amanda Roberts, Giordano de Guglielmo, Olivier George, John Light, Mike Stoolmiller, Susan Quello, Michael Skinner, Farhad Shadan, Adnan Begovic, Mark C. Kyle, R. Adron Harris
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Neurobiology of Stress
Subjects:
Fenofibrate
Alcohol use disorder
Peroxisome proliferator-activated receptor-alpha
Human laboratory study
Mouse
Rat
Online Access:http://www.sciencedirect.com/science/article/pii/S2352289523000929

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http://www.sciencedirect.com/science/article/pii/S2352289523000929

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