Methylated cis-regulatory elements mediate KLF4-dependent gene transactivation and cell migration

Methylated cis-regulatory elements mediate KLF4-dependent gene transactivation and cell migration

Altered DNA methylation status is associated with human diseases and cancer; however, the underlying molecular mechanisms remain elusive. We previously identified many human transcription factors, including Krüppel-like factor 4 (KLF4), as sequence-specific DNA methylation readers that preferentiall...

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Bibliographic Details
Main Authors: Jun Wan, Yijing Su, Qifeng Song, Brian Tung, Olutobi Oyinlade, Sheng Liu, Mingyao Ying, Guo-li Ming, Hongjun Song, Jiang Qian, Heng Zhu, Shuli Xia
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-05-01
Series:eLife
Subjects:
DNA methylation
histone modification
cell migration
KLF4
Online Access:https://elifesciences.org/articles/20068

Internet

https://elifesciences.org/articles/20068

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