Spleen tyrosine kinase mediates the γδTCR signaling required for γδT cell commitment and γδT17 differentiation

Spleen tyrosine kinase mediates the γδTCR signaling required for γδT cell commitment and γδT17 differentiation

The γδT cells that produce IL-17 (γδT17 cells) play a key role in various pathophysiologic processes in host defense and homeostasis. The development of γδT cells in the thymus requires γδT cell receptor (γδTCR) signaling mediated by the spleen tyrosine kinase (Syk) family proteins, Syk and Zap70. H...

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Bibliographic Details
Main Authors: Ryunosuke Muro, Tomoya Narita, Takeshi Nitta, Hiroshi Takayanagi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
γδT cell
TCR signal
SYK (spleen tyrosine kinase)
IL-17
thymus
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1045881/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1045881/full

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