Shear-responsive boundary-lubricated hydrogels attenuate osteoarthritis

Shear-responsive boundary-lubricated hydrogels attenuate osteoarthritis

Lipid-based boundary layers formed on liposome-containing hydrogels can facilitate lubrication. However, these boundary layers can be damaged by shear, resulting in decreased lubrication. Here, a shear-responsive boundary-lubricated drug-loaded hydrogel is created by incorporating celecoxib (CLX)-lo...

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Bibliographic Details
Main Authors: Yiting Lei, Xingkuan Wang, Junyi Liao, Jieliang Shen, Yuling Li, Zhengwei Cai, Ning Hu, Xiaoji Luo, Wenguo Cui, Wei Huang
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2022-10-01
Series:Bioactive Materials
Subjects:
Boundary lubrication
Injectable hydrogels
Shear-responsive
Liposomes
Osteoarthritis
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X22000780

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http://www.sciencedirect.com/science/article/pii/S2452199X22000780

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