Shear-responsive boundary-lubricated hydrogels attenuate osteoarthritis
Lipid-based boundary layers formed on liposome-containing hydrogels can facilitate lubrication. However, these boundary layers can be damaged by shear, resulting in decreased lubrication. Here, a shear-responsive boundary-lubricated drug-loaded hydrogel is created by incorporating celecoxib (CLX)-lo...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2022-10-01
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| Series: | Bioactive Materials |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X22000780 |
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| author | Yiting Lei Xingkuan Wang Junyi Liao Jieliang Shen Yuling Li Zhengwei Cai Ning Hu Xiaoji Luo Wenguo Cui Wei Huang |
| author_facet | Yiting Lei Xingkuan Wang Junyi Liao Jieliang Shen Yuling Li Zhengwei Cai Ning Hu Xiaoji Luo Wenguo Cui Wei Huang |
| author_sort | Yiting Lei |
| collection | DOAJ |
| description | Lipid-based boundary layers formed on liposome-containing hydrogels can facilitate lubrication. However, these boundary layers can be damaged by shear, resulting in decreased lubrication. Here, a shear-responsive boundary-lubricated drug-loaded hydrogel is created by incorporating celecoxib (CLX)-loaded liposomes within dynamic covalent bond-based hyaluronic acid (HA) hydrogels (CLX@Lipo@HA-gel). The dynamic cross-linked network enables the hydrogel to get restructured in response to shear, and the HA matrix allows the accumulation of internal liposome microreservoirs on the sliding surfaces, which results in the formation of boundary layers to provide stable lubrication. Moreover, hydration shells formed surrounding the hydrogel can retard the degradation process, thus helping in sustaining lubrication. Furthermore, in vitro and in vivo experiments found that CLX@Lipo@HA-gels can maintain anabolic-catabolic balance, alleviate cartilage wear, and attenuate osteoarthritis progression by delivering CLX and shear-responsive boundary lubrication. Overall, CLX@Lipo@HA-gels can serve as shear-responsive boundary lubricants and drug-delivery vehicles to alleviate friction-related diseases like osteoarthritis. |
| first_indexed | 2024-04-24T08:21:57Z |
| format | Article |
| id | doaj.art-d71c9a9b2c4549ab810b7fb924cb8946 |
| institution | Directory Open Access Journal |
| issn | 2452-199X |
| language | English |
| last_indexed | 2024-04-24T08:21:57Z |
| publishDate | 2022-10-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Bioactive Materials |
| spelling | doaj.art-d71c9a9b2c4549ab810b7fb924cb89462024-04-17T00:44:13ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2022-10-0116472484Shear-responsive boundary-lubricated hydrogels attenuate osteoarthritisYiting Lei0Xingkuan Wang1Junyi Liao2Jieliang Shen3Yuling Li4Zhengwei Cai5Ning Hu6Xiaoji Luo7Wenguo Cui8Wei Huang9Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Orthopedic Laboratory of Chongqing Medical University, No.1 Youyi Road, Yuzhong District, Chongqing, 400016, PR ChinaDepartment of Orthopaedics, Affiliated Hospital of North Sichuan Medical College, No. 1 the South of Maoyuan Road, Nanchong, Sichuan, 637000, PR ChinaDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Orthopedic Laboratory of Chongqing Medical University, No.1 Youyi Road, Yuzhong District, Chongqing, 400016, PR ChinaDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Orthopedic Laboratory of Chongqing Medical University, No.1 Youyi Road, Yuzhong District, Chongqing, 400016, PR ChinaDepartment of Orthopaedics, Affiliated Hospital of North Sichuan Medical College, No. 1 the South of Maoyuan Road, Nanchong, Sichuan, 637000, PR ChinaDepartment of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, PR ChinaDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Orthopedic Laboratory of Chongqing Medical University, No.1 Youyi Road, Yuzhong District, Chongqing, 400016, PR ChinaDepartment of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Orthopedic Laboratory of Chongqing Medical University, No.1 Youyi Road, Yuzhong District, Chongqing, 400016, PR China; Corresponding author.Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, PR China; Corresponding author.Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Orthopedic Laboratory of Chongqing Medical University, No.1 Youyi Road, Yuzhong District, Chongqing, 400016, PR China; Corresponding author.Lipid-based boundary layers formed on liposome-containing hydrogels can facilitate lubrication. However, these boundary layers can be damaged by shear, resulting in decreased lubrication. Here, a shear-responsive boundary-lubricated drug-loaded hydrogel is created by incorporating celecoxib (CLX)-loaded liposomes within dynamic covalent bond-based hyaluronic acid (HA) hydrogels (CLX@Lipo@HA-gel). The dynamic cross-linked network enables the hydrogel to get restructured in response to shear, and the HA matrix allows the accumulation of internal liposome microreservoirs on the sliding surfaces, which results in the formation of boundary layers to provide stable lubrication. Moreover, hydration shells formed surrounding the hydrogel can retard the degradation process, thus helping in sustaining lubrication. Furthermore, in vitro and in vivo experiments found that CLX@Lipo@HA-gels can maintain anabolic-catabolic balance, alleviate cartilage wear, and attenuate osteoarthritis progression by delivering CLX and shear-responsive boundary lubrication. Overall, CLX@Lipo@HA-gels can serve as shear-responsive boundary lubricants and drug-delivery vehicles to alleviate friction-related diseases like osteoarthritis.http://www.sciencedirect.com/science/article/pii/S2452199X22000780Boundary lubricationInjectable hydrogelsShear-responsiveLiposomesOsteoarthritis |
| spellingShingle | Yiting Lei Xingkuan Wang Junyi Liao Jieliang Shen Yuling Li Zhengwei Cai Ning Hu Xiaoji Luo Wenguo Cui Wei Huang Shear-responsive boundary-lubricated hydrogels attenuate osteoarthritis Bioactive Materials Boundary lubrication Injectable hydrogels Shear-responsive Liposomes Osteoarthritis |
| title | Shear-responsive boundary-lubricated hydrogels attenuate osteoarthritis |
| title_full | Shear-responsive boundary-lubricated hydrogels attenuate osteoarthritis |
| title_fullStr | Shear-responsive boundary-lubricated hydrogels attenuate osteoarthritis |
| title_full_unstemmed | Shear-responsive boundary-lubricated hydrogels attenuate osteoarthritis |
| title_short | Shear-responsive boundary-lubricated hydrogels attenuate osteoarthritis |
| title_sort | shear responsive boundary lubricated hydrogels attenuate osteoarthritis |
| topic | Boundary lubrication Injectable hydrogels Shear-responsive Liposomes Osteoarthritis |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X22000780 |
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