Benzylisoquinoline alkaloids inhibit lung fibroblast activation mainly via inhibiting TGF-β1/Smads and ERK1/2 pathway proteins

Benzylisoquinoline alkaloids inhibit lung fibroblast activation mainly via inhibiting TGF-β1/Smads and ERK1/2 pathway proteins

Backgrounds: Liensinine (Lien), Neferine (Nef), Isoliensinine (Iso) and Tetrandrine (Tet), benzylisoquinoline alkaloids (BIAs), have been shown inhibitory effects on pulmonary fibrosis (PF) through anti-inflammatory, anti-oxidative activities, inhibition of cytokines and NF-κB. Effects of other simi...

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Bibliographic Details
Main Authors: Hui-Li Ren, Jia-Hua Zhang, Jun-Hua Xiao
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Heliyon
Subjects:
Benzylisoquinoline alkaloids
Lung fibroblasts
Pulmonary fibrosis
TGF-β1
Smad3/4
p-ERK1/2
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023040562

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http://www.sciencedirect.com/science/article/pii/S2405844023040562

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