DISSECTING COMPLEX POLYKETIDE BIOSYNTHESIS
Numerous bioactive natural products are synthesised by modular polyketide synthases. These compounds can be made in high yield by native multienzyme assembly lines. However, formation of analogues by genetically engineered systems is often considerably less efficient. Biochemical studies on intact p...
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| Format: | Article |
| Language: | English |
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Elsevier
2012-10-01
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| Series: | Computational and Structural Biotechnology Journal |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2001037014600660 |