Error and error mitigation in low-coverage genome assemblies.

The recent release of twenty-two new genome sequences has dramatically increased the data available for mammalian comparative genomics, but twenty of these new sequences are currently limited to ∼2× coverage. Here we examine the extent of sequencing error in these 2× assemblies, and its potential im...

Full description

Bibliographic Details
Main Authors: Melissa J Hubisz, Michael F Lin, Manolis Kellis, Adam Siepel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-02-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3038916?pdf=render