IMP/GTP balance modulates cytoophidium assembly and IMPDH activity

IMP/GTP balance modulates cytoophidium assembly and IMPDH activity

Abstract Background Inosine monophosphate dehydrogenase (IMPDH), the rate-limiting enzyme in de novo GTP biosynthesis, plays an important role in cell metabolism and proliferation. It has been demonstrated that IMPDH can aggregate into a macrostructure, termed the cytoophidium, in mammalian cells un...

Full description

Bibliographic Details
Main Authors: Gerson Dierley Keppeke, Chia Chun Chang, Min Peng, Li-Yu Chen, Wei-Cheng Lin, Li-Mei Pai, Luis Eduardo Coelho Andrade, Li-Ying Sung, Ji-Long Liu
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Cell Division
Subjects:
Cytoophidium
IMPDH enzyme
GTP biosynthesis
IMP
Cell proliferation
Online Access:http://link.springer.com/article/10.1186/s13008-018-0038-0

Internet

http://link.springer.com/article/10.1186/s13008-018-0038-0

Similar Items