Genomic landscape and efficacy of HER2-targeted therapy in patients with HER2-mutant non-small cell lung cancer

Genomic landscape and efficacy of HER2-targeted therapy in patients with HER2-mutant non-small cell lung cancer

BackgroundHER2-targeted therapy provides survival benefits to HER2-mutant non-small cell lung cancer (NSCLC). A better understanding of the clinical and genomic characterization of treatment-naïve HER2-positive NSCLC, as well as the efficacy of and resistance to HER2-targeted therapy in HER2-altered...

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Bibliographic Details
Main Authors: Yanjie Han, Yuanyuan Xiong, Tao Lu, Rongrong Chen, Yuan Liu, Hui Tang, Ruixuan Geng, Yingyi Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Oncology
Subjects:
HER2
non-small cell lung cancer
HER2-TKI
resistance mechanism
targeted sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1121708/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2023.1121708/full

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