Modular bioengineering of whole-cell catalysis for sialo-oligosaccharide production: coordinated co-expression of CMP-sialic acid synthetase and sialyltransferase

Modular bioengineering of whole-cell catalysis for sialo-oligosaccharide production: coordinated co-expression of CMP-sialic acid synthetase and sialyltransferase

Abstract Background In whole-cell bio-catalysis, the biosystems engineering paradigm shifts from the global reconfiguration of cellular metabolism as in fermentation to a more focused, and more easily modularized, optimization of comparably short cascade reactions. Human milk oligosaccharides (HMO) ...

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Bibliographic Details
Main Authors: Sabine Schelch, Manuel Eibinger, Jasmin Zuson, Jürgen Kuballa, Bernd Nidetzky
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Microbial Cell Factories
Subjects:
Sialo-oligosaccharides
3ʹ-Sialyllactose
α2,3‐Sialyltransferase
Whole-cell bio-catalysis
Multienzyme cascade reaction
Co-expression
Online Access:https://doi.org/10.1186/s12934-023-02249-1

Internet

https://doi.org/10.1186/s12934-023-02249-1

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