Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis

Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis

Elevated plasma LDL cholesterol levels increase the risk of atherosclerotic cardiovascular disease. Here, the authors show that inhibition of MT1-MMP reduces plasma LDL cholesterol levels and the risk of atherosclerosis, indicating the potential of MT1-MMP inhibition as a lipid-lowering therapy.

Bibliographic Details
Main Authors: Adekunle Alabi, Xiao-Dan Xia, Hong-Mei Gu, Faqi Wang, Shi-Jun Deng, Nana Yang, Ayinuer Adijiang, Donna N. Douglas, Norman M. Kneteman, Yazhuo Xue, Li Chen, Shucun Qin, Guiqing Wang, Da-Wei Zhang
Format: Article
Language:English
Published: Nature Portfolio 2021-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-22167-3

Internet

https://doi.org/10.1038/s41467-021-22167-3

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