Membrane type 1 matrix metalloproteinase promotes LDL receptor shedding and accelerates the development of atherosclerosis
Elevated plasma LDL cholesterol levels increase the risk of atherosclerotic cardiovascular disease. Here, the authors show that inhibition of MT1-MMP reduces plasma LDL cholesterol levels and the risk of atherosclerosis, indicating the potential of MT1-MMP inhibition as a lipid-lowering therapy.
Bibliographic Details
| Main Authors: |
Adekunle Alabi,
Xiao-Dan Xia,
Hong-Mei Gu,
Faqi Wang,
Shi-Jun Deng,
Nana Yang,
Ayinuer Adijiang,
Donna N. Douglas,
Norman M. Kneteman,
Yazhuo Xue,
Li Chen,
Shucun Qin,
Guiqing Wang,
Da-Wei Zhang |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2021-03-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-021-22167-3
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