Network- and enrichment-based inference of phenotypes and targets from large-scale disease maps

Abstract Complex diseases are inherently multifaceted, and the associated data are often heterogeneous, making linking interactions across genes, metabolites, RNA, proteins, cellular functions, and clinically relevant phenotypes a high-priority challenge. Disease maps have emerged as knowledge bases...

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Bibliographic Details
Main Authors: Matti Hoch, Suchi Smita, Konstantin Cesnulevicius, David Lescheid, Myron Schultz, Olaf Wolkenhauer, Shailendra Gupta
Format: Article
Language:English
Published: Nature Portfolio 2022-04-01
Series:npj Systems Biology and Applications
Online Access:https://doi.org/10.1038/s41540-022-00222-z