Single-molecule force spectroscopy of toehold-mediated strand displacement

Abstract Toehold-mediated strand displacement (TMSD) is extensively utilized in dynamic DNA nanotechnology and for a wide range of DNA or RNA-based reaction circuits. Investigation of TMSD kinetics typically relies on bulk fluorescence measurements providing effective, bulk-averaged reaction rates....

Full description

Bibliographic Details
Main Authors: Andreas Walbrun, Tianhe Wang, Michael Matthies, Petr Šulc, Friedrich C. Simmel, Matthias Rief
Format: Article
Language:English
Published: Nature Portfolio 2024-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-51813-9