Structural classification of MELK inhibitors and prospects for the treatment of tumor resistance: A review

Maternal embryonic leucine zipper kinase (MELK), a member of the AMP-related serine-threonine kinase family, has been involved in regulating many cellular events, and aberrant MELK expression is associated with tumorigenesis and malignant progression in various cancers. More and more studies have fo...

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Bibliographic Details
Main Authors: Ling Ren, Jing-si Guo, Yu-heng Li, Gang Dong, Xin-yang Li
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222013543