Eribulin, Child-Pugh score, and liver-function tests: lessons from pivotal breast cancer studies 301 and 305

Eribulin, Child-Pugh score, and liver-function tests: lessons from pivotal breast cancer studies 301 and 305

Abstract Background The recommended starting dose of eribulin in patients with hepatic impairment is based on the Child-Pugh score, largely informed by a pharmacokinetic study of 18 patients. In the pivotal studies of eribulin in metastatic breast cancer (Study 301 and Study 305 [EMBRACE]), entry cr...

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Bibliographic Details
Main Authors: Iain R. Macpherson, Yaohua He, Carlo Palmieri
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Breast Cancer Research
Subjects:
Breast cancer
Eribulin
Bilirubin
Liver-function tests
Child-Pugh score
Online Access:https://doi.org/10.1186/s13058-021-01407-w

Internet

https://doi.org/10.1186/s13058-021-01407-w

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