Modulation of cell signaling networks after CTLA4 blockade in patients with metastatic melanoma.

Modulation of cell signaling networks after CTLA4 blockade in patients with metastatic melanoma.

The effects on cell signalling networks upon blockade of cytotoxic T lymphocyte-associated antigen-4 (CTLA4) using the monoclonal antibody tremelimumab were studied in peripheral blood mononuclear cell (PBMC) samples from patients with metastatic melanoma.Findings Intracellular flow cytometry was us...

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Bibliographic Details
Main Authors: Begoña Comin-Anduix, Hooman Sazegar, Thinle Chodon, Douglas Matsunaga, Jason Jalil, Erika von Euw, Helena Escuin-Ordinas, Robert Balderas, Bartosz Chmielowski, Jesus Gomez-Navarro, Richard C Koya, Antoni Ribas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-09-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2939876?pdf=render

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http://europepmc.org/articles/PMC2939876?pdf=render

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