The Adhesion G Protein-Coupled Receptor GPR97/ADGRG3 Is Expressed in Human Granulocytes and Triggers Antimicrobial Effector Functions

The Adhesion G Protein-Coupled Receptor GPR97/ADGRG3 Is Expressed in Human Granulocytes and Triggers Antimicrobial Effector Functions

The adhesion family of G protein-coupled receptors (aGPCRs) comprises 33 members in human, several of which are distinctly expressed and functionally involved in polymorphonuclear cells (PMNs). As former work indicated the possible presence of the aGPCR GPR97 in granulocytes, we studied its cellular...

Full description

Bibliographic Details
Main Authors: Cheng-Chih Hsiao, Tai-Ying Chu, Chia-Jung Wu, Maartje van den Biggelaar, Caroline Pabst, Josée Hébert, Taco W. Kuijpers, Brendon P. Scicluna, Kuan-Yu I, Tse-Ching Chen, Ines Liebscher, Jörg Hamann, Hsi-Hsien Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Immunology
Subjects:
adhesion GPCR
monoclonal antibody
granulocytes
inflammation
G-protein signaling
antimicrobial activity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02830/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02830/full

Similar Items