Guarding the Genome: CENP-A-Chromatin in Health and Cancer

Faithful chromosome segregation is essential for the maintenance of genomic integrity and requires functional centromeres. Centromeres are epigenetically defined by the histone H3 variant, centromere protein A (CENP-A). Here we highlight current knowledge regarding CENP-A-containing chromatin struct...

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Bibliographic Details
Main Authors: Megan A. Mahlke, Yael Nechemia-Arbely
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Genes
Subjects:
Online Access:https://www.mdpi.com/2073-4425/11/7/810