An integrated microfluidics platform with high-throughput single-cell cloning array and concentration gradient generator for efficient cancer drug effect screening

An integrated microfluidics platform with high-throughput single-cell cloning array and concentration gradient generator for efficient cancer drug effect screening

Abstract Background Tumor cell heterogeneity mediated drug resistance has been recognized as the stumbling block of cancer treatment. Elucidating the cytotoxicity of anticancer drugs at single-cell level in a high-throughput way is thus of great value for developing precision therapy. However, curre...

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Bibliographic Details
Main Authors: Biao Wang, Bang-Shun He, Xiao-Lan Ruan, Jiang Zhu, Rui Hu, Jie Wang, Ying Li, Yun-Huang Yang, Mai-Li Liu
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Military Medical Research
Subjects:
Microfluidics
Single-cell analysis
Leukemia
High-throughput drug screening
Single-cell cloning
Online Access:https://doi.org/10.1186/s40779-022-00409-9

Internet

https://doi.org/10.1186/s40779-022-00409-9

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