Novel Conformation-Dependent Tau Antibodies Are Modulated by Adjacent Phosphorylation Sites

Novel Conformation-Dependent Tau Antibodies Are Modulated by Adjacent Phosphorylation Sites

Tau proteins within the adult central nervous system (CNS) are found to be abnormally aggregated into heterogeneous filaments in neurodegenerative diseases, termed tauopathies. These tau inclusions are pathological hallmarks of Alzheimer’s disease (AD), Pick’s disease (PiD), corticobasal degeneratio...

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Bibliographic Details
Main Authors: Giavanna Paterno, Jose Torrellas, Brach M. Bell, Kimberly-Marie M. Gorion, Stephan S. Quintin, Gabriela P. Hery, Stefan Prokop, Benoit I. Giasson
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:International Journal of Molecular Sciences
Subjects:
tau
antibodies
phosphorylation
conformation
pathological
neuropathology
Online Access:https://www.mdpi.com/1422-0067/24/18/13676

Internet

https://www.mdpi.com/1422-0067/24/18/13676

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