Hierarchical structural component model for pathway analysis of common variants

Hierarchical structural component model for pathway analysis of common variants

Abstract Background Genome-wide association studies (GWAS) have been widely used to identify phenotype-related genetic variants using many statistical methods, such as logistic and linear regression. However, GWAS-identified SNPs, as identified with stringent statistical significance, explain just a...

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Bibliographic Details
Main Authors: Nan Jiang, Sungyoung Lee, Taesung Park
Format: Article
Language:English
Published: BMC 2020-02-01
Series:BMC Medical Genomics
Subjects:
Common variants
Genome-wide association study
Hierarchical components
Pathway analysis
Online Access:http://link.springer.com/article/10.1186/s12920-019-0650-0

Internet

http://link.springer.com/article/10.1186/s12920-019-0650-0

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