Metformin Attenuates Inflammatory Responses and Enhances Antibody Production in an Acute Pneumonia Model of Streptococcus pneumoniae

Metformin Attenuates Inflammatory Responses and Enhances Antibody Production in an Acute Pneumonia Model of Streptococcus pneumoniae

Metformin may potentially reverse various age-related conditions; however, it is unclear whether metformin can also mitigate or delay the deterioration of immunological resilience that occurs in the context of infections that are commonly observed in older persons. We examined whether metformin prom...

Full description

Bibliographic Details
Main Authors: Grace C. Lee, Alvaro G. Moreira, Cecilia Hinojosa, Raymond Benavides, Caitlyn Winter, Audrey C. Anderson, Chang-Jui Chen, Noemi Borsa, Gabrielyd Hastings, Cody A. Black, Sarah M. Bandy, Alexander Shaffer, Marcos I. Restrepo, Sunil K. Ahuja
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Aging
Subjects:
Streptococcus pneumoniae
vaccine response
metformin
aging
pneumonia
Online Access:https://www.frontiersin.org/articles/10.3389/fragi.2022.736835/full

Internet

https://www.frontiersin.org/articles/10.3389/fragi.2022.736835/full

Similar Items