Structural and dynamic determinants for highly selective RET kinase inhibition reveal cryptic druggability

Structural and dynamic determinants for highly selective RET kinase inhibition reveal cryptic druggability

Introduction: The structural and dynamic determinants that confer highly selective RET kinase inhibition are poorly understood. Objectives: To explore the druggability landscape of the RET active site in order to uncover structural and dynamic vulnerabilities that can be therapeutically exploited. M...

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Bibliographic Details
Main Authors: Moustafa A. Shehata, Julia Contreras, Ana Martín-Hurtado, Aurane Froux, Hossam Taha Mohamed, Ahmed A. El-Sherif, Iván Plaza-Menacho
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Journal of Advanced Research
Subjects:
Protein kinases
Oncogene
Structure-function
Targeted-therapies
Drug-discovery
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123222001163

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http://www.sciencedirect.com/science/article/pii/S2090123222001163

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