Canagliflozin inhibits inflammasome activation in diabetic endothelial cells – Revealing a novel calcium-dependent anti-inflammatory effect of canagliflozin on human diabetic endothelial cells

Canagliflozin inhibits inflammasome activation in diabetic endothelial cells – Revealing a novel calcium-dependent anti-inflammatory effect of canagliflozin on human diabetic endothelial cells

Background: Canagliflozin (CANA) shows anti-inflammatory and anti-oxidative effects on endothelial cells (ECs). In diabetes mellitus (DM), excessive reactive oxygen species (ROS) generation, increased intracellular calcium (Ca2+) and enhanced extracellular signal regulated kinase (ERK) 1/2 phosphory...

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Bibliographic Details
Main Authors: Xiaoling Li, Raphaela P. Kerindongo, Benedikt Preckel, Jan-Ole Kalina, Markus W. Hollmann, Coert J. Zuurbier, Nina C. Weber
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Canagliflozin (CANA)
Reactive oxygen species (ROS)
Intracellular calcium (Ca2+)
Extracellular signal regulated kinase (ERK) 1/2 phosphorylation
Interleukin (IL)− 1β
Nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) inflammasome
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223000161

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http://www.sciencedirect.com/science/article/pii/S0753332223000161

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