Rescue of a Vaccinia Virus Mutant Lacking IFN Resistance Genes K1L and C7L by the Parapoxvirus Orf Virus

Rescue of a Vaccinia Virus Mutant Lacking IFN Resistance Genes K1L and C7L by the Parapoxvirus Orf Virus

Type 1 interferons induce the upregulation of hundreds of interferon-stimulated genes (ISGs) that combat viral replication. The parapoxvirus orf virus (ORFV) induces acute pustular skin lesions in sheep and goats and can reinfect its host, however, little is known of its ability to resist IFN. Vacci...

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Bibliographic Details
Main Authors: Sherief Riad, Yan Xiang, Basheer AlDaif, Andrew A. Mercer, Stephen B. Fleming
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Microbiology
Subjects:
parapoxvirus
Orf virus
vaccinia virus
interferon
poxvirus
immune evasion
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.01797/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2020.01797/full

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