The Alzheimer’s Disease γ-Secretase Generates Higher 42:40 Ratios for β-Amyloid Than for p3 Peptides

The Alzheimer’s Disease γ-Secretase Generates Higher 42:40 Ratios for β-Amyloid Than for p3 Peptides

Alzheimer’s disease is characterized by intracerebral deposition of β-amyloid (Aβ). While Aβ40 is the most abundant form, neurotoxicity is mainly mediated by Aβ42. Sequential cleavage of amyloid precursor protein (APP) by β- and γ-secretases gives rise to full-length Aβ (Aβ1-x) and N-terminally trun...

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Bibliographic Details
Main Authors: Gabriele Siegel, Hermeto Gerber, Philipp Koch, Oliver Bruestle, Patrick C. Fraering, Lawrence Rajendran
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Cell Reports
Subjects:
Alzheimer’s disease
amyloid precursor protein
beta-Amyloid
p3 peptide
gamma-secretase
APP CTF
amyloidogenic pathway
AICD
primary neurons
iPS cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717306769

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http://www.sciencedirect.com/science/article/pii/S2211124717306769

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