Compressive mechanical stress enhances susceptibility to interleukin-1 by increasing interleukin-1 receptor expression in 3D-cultured ATDC5 cells

Compressive mechanical stress enhances susceptibility to interleukin-1 by increasing interleukin-1 receptor expression in 3D-cultured ATDC5 cells

Abstract Background Mechanical overload applied on the articular cartilage may play an important role in the pathogenesis of osteoarthritis. However, the mechanism of chondrocyte mechanotransduction is not fully understood. The purpose of this study was to assess the effects of compressive mechanica...

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Bibliographic Details
Main Authors: Yuki Takeda, Yasuo Niki, Yusuke Fukuhara, Yoshitsugu Fukuda, Kazuhiko Udagawa, Masayuki Shimoda, Toshiyuki Kikuchi, Shu Kobayashi, Kengo Harato, Takeshi Miyamoto, Morio Matsumoto, Masaya Nakamura
Format: Article
Language:English
Published: BMC 2021-03-01
Series:BMC Musculoskeletal Disorders
Subjects:
3D-cultured ATDC5 cells
Cyclic compressive loading
Interleukin-1
Transient receptor potential vanilloid 4
Online Access:https://doi.org/10.1186/s12891-021-04095-x

Internet

https://doi.org/10.1186/s12891-021-04095-x

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