<i>Padi2/3</i> Deficiency Alters the Epigenomic Landscape and Causes Premature Differentiation of Mouse Trophoblast Stem Cells

<i>Padi2/3</i> Deficiency Alters the Epigenomic Landscape and Causes Premature Differentiation of Mouse Trophoblast Stem Cells

Histone citrullination is a relatively poorly studied epigenetic modification that involves the irreversible conversion of arginine residues into citrulline. It is conferred by a small family of enzymes known as protein arginine deiminases (PADIs). PADI function supports the pluripotent state of emb...

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Bibliographic Details
Main Authors: Noura N. Ballasy, Elizabeth A. Bering, Caroline Kokorudz, Bethany N. Radford, Xiang Zhao, Wendy Dean, Myriam Hemberger
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cells
Subjects:
PADI
histone citrullination
DNA methylation
trophoblast stem cells
trophoblast giant cells
epigenetic regulation
Online Access:https://www.mdpi.com/2073-4409/11/16/2466

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https://www.mdpi.com/2073-4409/11/16/2466

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